This won't hurt a bit - it'll hurt a lot Print E-mail
Tuesday, 23 March 2010 16:00
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Healthcare spending in the developed world is going through the roof. Big business and bad diets are getting the blame. But the taboo truth is we are all getting sicker, says Eamonn Dywer, and medicine itself may be responsible.


As Obamacare wheezes its way over the finish line, a pro-market British think tank has opened the battle lines on health care costs at home.


“The NHS should not be immune from the drive to cut public spending,” the report said, and suggested slashing beds by 25 per cent.


Under New Labour, NHS spending had ballooned from £35 billion to over £104 billion. Yet perversely, polls have found people do not believe this has improved the delivery of health care.


The disparity between increased spending and standstill service delivery has been blamed on parasitic pen pushers and middle managers. When politicians talk about cuts to the NHS they allude to a magic scalpel that razors away the fat and leaves the muscle lean. Undoubtedly, disasters such as the NHS IT system (£12 billion pissed down the drain and counting) and billions more on consultants have made the NHS much less efficient. Because the NHS is free at the point of use, we tend not to think of it in terms of healthcare costs.


However, in real terms, healthcare costs have been rising worldwide. In America, spending on health care now represents 16 per cent of GDP. Obama’s stated aim in passing health care reform was targeting spiralling costs.


The poison diets and ageing population of the developed world are important factors in this. But one of the reasons for increased spending on medicine is counter-productive. The more advanced medicine becomes, the more it costs. Let’s say a procedure becomes cheaper; more people can afford it, and costs can actually increase overall – a kind of Jevon’s Paradox. While individual procedures and treatments may become cheaper or more efficient over time, as medicine finds ways of treating conditions that were previously untreatable, overall costs increase.


But one underlying reason for rising health care costs is taboo: as a result of over a century of advanced medical intervention, we are becoming more genetically unfit.


A bitter pill to swallow

Take Type 1 childhood diabetes. Untreated it is a lethal condition, causing diabetic kino-acidosis. In 1922, in one of the most famous moments in medical history, the inventors of insulin injected 50 dying children on a ward. So dramatically effective were the results that ‘before they had reached the last dying child, the first few were awakening from their coma, to the joyous exclamations of their families.’


As a result of insulin’s discovery, sufferers can live a full reproductive life. What was once a death sentence is now an inconvenience. Unfortunately, susceptibility to the disease is genetically inherited, and it has grown increasingly prevalent over the 20th century. In America, an estimated 5-10 per cent of the population now have diabetes. It is arguable that at least a factor in this increase is ‘genetic drift’ – the process whereby inherited characteristics neutral to selection become increasingly prevalent.


W.D. Hamilton, one of the 20th century’s leading geneticists, was deeply concerned by the rise of diabetes and other genetically inherited diseases. In his essay The Hospitals Are Coming, he took these concerns to their natural conclusion:


“If everyone was diabetic, the operatives in the factory making insulin had better not join in any general strike or they may end up killing themselves along with the rest of us. In the midst of such a crisis, the only survivors would some lucky people on a South Pacific island who had never had any medical attention and so were still competent.”


The issue with rising healthcare costs is that there is literally no limit to them. In Hamilton’s nightmare vision of a genetically unchecked future, he imagines a global economy that has become a planetary hospital, a ‘super organism’, in which the least feeble and sick are the orderlies and technicians.


The counter to this argument is exemplified by Richard Dawkins’ The Extended Phenotype. Dawkins rejected his academic ideologue’s pessimistic view. Inasmuch as a beaver’s dam is an expression of a beaver’s genes, medical infrastructure is an expression of mankind’s genes. We may be becoming more ‘genetically unfit’ if we view our health stripped of hospitals and medication, but why make the distinction? Dawkins would argue the caesarean section is as much an expression of our genes as the natural birth.


But what can stop the increasing portion of the economy dedicated to tending to increasingly ill patients? Dawkins would argue that we will find technical solutions to genetic crises. Along with geneticists like John Maynard Smith, they point to hypothetical ‘germ-line’ solutions in which boffins correct dangerous mutations and maintain the fitness of the human race.


Technological breakdown

There are however, a huge number of obstacles to gene therapy. Scientists have now been trying for decades to discover the genetic causes of diseases. What they have found is that in almost no cases are single genes responsible for traits. Even popular science writer Steve Jones, President of the Galton Institute (formerly the Eugenics Society) has abandoned hope of discovering more than a tiny portion of life’s secrets from our genes.

By definition, if we can’t work out the language that life has been coded in, we cannot hope to programme it ourselves.


While these science-fiction, techno-fix solutions remain so much hot air, the reality of rising healthcare costs continues unimpeded. The obvious solution, which Hamilton openly supported, is some form of eugenics. It’s a word that almost immediately evokes Nazi death camps. Yet before the Second World War, prominent members of the Eugenics Society included John Maynard Keynes and Neville Chamberlain. It was common among intellectuals on the left to ruminate on the future genetic stock of their ‘race’.


Of course, ideas of racial purity and superiority have become hopelessly outmoded. Indeed, Hamilton argued for interracial marriage as way of improving the human race’s fitness. But the basic, intuitive premise of eugenics remains relevant. With the removal of natural selection from our species, what ‘other processes that are more merciful and not less effective’ shall we replace it with?


Modern eugenics is not just restricted to China. It is carried out on a daily basis in the developed world. The vast majority of women whose foetus shows susceptibility towards Down’s syndrome opt to end the pregnancy. It is common for Jewish couples to take genetic tests before marriage – and to call off the nuptials if they don’t get the all clear. Both are classic examples of negative eugenics.


Nor is it a modern solution; the pre-Christian peoples of the Inuit, the Native Americans, and the Sami people of the North had stable, healthy populations. Missionaries were horrified to find they would kill unwanted or sickly babies through exposure.


As someone concerned with unprecedented near-term catastrophes such as Peak Oil, climate change and overpopulation, I think we have much more pressing crises to solve than the long-term health of the species. But the designers of the permanent societies of tomorrow need to think seriously about how they can break the arms race between modern medicine and genetic deterioration. If you believe advanced technology is not the answer to all our problems, then you may need to find solutions that seem unpalatable to our society of today.

eamonn.dwyer83@gmail.com
http://www.twitter.com/eamonndwyer

Last Updated on Tuesday, 30 March 2010 23:21
 
Comments (9)
re: P Maguire Part 2
9 Sunday, 28 March 2010 16:24
Eamonn Dwyer
Maguire is not disputing my central point; that the increase in genetic susceptibility Type 1 diabetes represents a decrease in the fitness of the species. Instead, he focuses on other, much more important contemporary factors in disease, in addition to the disgracefully wasteful spending in the West which allows those in the developed world to die from easily preventable disease. But these are separate points!

To some extent, this is my fault, as I placed the article in the context of contemporary cost increases in health care. What I am talking about will emerge as a massive crisis in the next eighty years (as Hamilton suggested) if civilisation continues to develop at current rates of growth (I think we're for some pretty rough times, and I'm essentially looking at a post-collapse, stable state economy). So you can place the 'crisis' on a time-scale of hundreds of years. And it's about we started talking about what geneticists are quietly saying in the corridors of Academia (but not in their papers).
Re: P Maguire
8 Sunday, 28 March 2010 16:23
Eamonn Dwyer
P Maguire rightly flags up the massive impact of ageing populations and the emergence of post-reproductive age gene expression. For example, many diseases which best us in old age may well be carried in us by a form of genetic drift - as our unusually long lifespans plumb the full unselected depths of our inheritance. Maguire is absolutely right that a far more important factor right now is prolonged lifespan. But that's the key phrase - right now. I never claimed the majority of medical cost increases were due to reduced human fitness.

Let's take Type 1 diabetes; I said 'It is arguable that at least a factor in this increase is ‘genetic drift’ – the process whereby inherited characteristics neutral to selection become increasingly prevalent.' 'It is arguable... at least a factor' a very strong qualifying statements.

I disagree with Maguire's general assertion about Diabetes. There is a 40% correlation, not 30% , between identical twins. http://www.sciencedaily.com/releases/2009/03/090305141639.htm . Irrespective of the figures, genes play a hugely important role in diabetes, and underline many, many diseases. The children of those with Type 1 Diabetes who can now lead a full reproductive life, by my calculation would have a 1/5 chance of contracting the disease. More anecdotally, my family has a long history of diabetes, so I speak not just from the text book, but from the photo album.
Re: Get Your Facts Right
7 Friday, 26 March 2010 16:32
Eamonn Dwyer
Thank you for your considered opinions.

When I said genetic testing was 'common' for Jewish couples, I did not mean most couples went through with it, I meant it was 'not unusual'. I think there is very interesting research into the connection between higher rates of genetic diseases and higher IQ among Jewish people, which hints that the same genes may be responsible for both - see http://www.gnxp.com/MT2/archives/000777.html (rather technical but interesting).

Please read my other article. I believe everyone has a right to a great sex life. I am a massive supporter of free contraception. But I think if someone has severe, heritable disabilities and wish to have children, it is worth -considering- adoption or donor sperms or eggs. I don't believe this is a radical suggestion. However, the involvement of the state is something that needs to be debated in a public forum because our hopes for a future in which we could 'fix' deleterious genes is looking increasingly unlikely. The absolute evils of Nazi eugenics programs should not forbid us from investigating any form of artificial selection, which as I argue are already in practice anyway.

Population policies can be painless (as in Iran), or they can be painful (as in China). One thing is certain; the later you implement them, the more painful they will be, and the more of our rights we will need to individually sacrifice for the welfare of society and or children. There are competing human rights involved. Take abortion - the child has a right to life, but the mother has a right to choose. These are irreconcilable rights. What I am saying is there are no easy answers.

I am NOT suggesting reforming the NHS by introducing eugenical reforms. For more details, see my response to P Maguire.
resource rationing
6 Thursday, 25 March 2010 20:43
P Maguire
Of course when I refer to health spending in my comment below I'm talking about the situaion in economically developed parts of the world. there's definitely an issue regarding the value of increasingly advanced medical interventions in terms of the rationing of resources and the massive inequality that exists between wealthy countries and the rest of the world. we all conveiniently ignore the fact that choices regarding who lives and who dies are made on a daily basis in terms of what money is given to and what isn't - for example, if the entire year's budget of the NHS were to be cut and instead spent on improving the sanitary conditions of a third world city it would probably save more lives than it currently does (and younger lives at that).
gene pool not affected
5 Thursday, 25 March 2010 20:14
P Maguire
This is an interesting article and it is right that the effect of increased medical intervention on the general health of the population is not a taboo subject.

However there are a number of problems with the assertion that the human gene pool is becoming significantly distorted due to medical advances.

The article ignores the fact that the vast majority of health spending goes on treating the diseases of middle to old age. Since such patients are beyond reproductive age and indeed have already passed on their genes it makes no difference to the gene pool whether they live or die.

Regarding the specific example given of diabetes mellitus type 1 - this is an excellent example of a disease with a multifactorial aetiology. While there is undoubtedly a genetic link there are also significant environmental risk factors such as viral infection. The majority (75%) of DM1 patients have no family history of the illness and even in identical twins - with exactly the same DNA - there is only 1/3 concordance in development of the condition. The idea that the disease would disappear or even significantly reduce in prevalence if patients with the condition were allowed to die before passing on their genes is misguided. The very persistence of the illness for the thousands of years which preceeded the discovery of insulin demonstrates this.

I think a more realistic view is not that medical interventions are 'weakening' the gene pool. Rather, medical interventions are prolonging the life of the average person who in a previous era would have succombed to infection or poor nutrition. This allows genetic traits - which were always present - to express themselves in the aging population.
Get your facts right - part 4
4 Thursday, 25 March 2010 19:49
E.e.e
The NHS could save a great deal of money by being better organised. A doctor friend of mine estimates that 80% of hospital patients are malnourished. The reasons behind this are simple and should be easily prevented: special dietary requirements ignored, food left at the end of the bed for patients too ill to reach it, unpalatable food being served, food being taken away too quickly for slow eaters. Addressing this problem would cost a little more money upfront, but it would swiftly pay for itself and then some as patients would be in better health, be discharged from hospital sooner, and have a lower rate of complications. No one wants to spend more money on anything in the NHS, so simple measures such as these are unlikely to take place. Instead, we have ludicrous situations such as when someone spotted that junior doctors work horrific hours, and an official cap was placed on junior doctors' hours. They didn't provide any more doctors to do the work for when these junior doctors supposedly went home, so of course what happened was that timesheets were falsified and the now-underpaid junior doctors were warned that if they wrote down their real hours (so that they could be paid for the hours they had actually worked, rather than the hours they were meant to have worked), they would lose their jobs. You're looking in the wrong place to reform the NHS.
Get your facts right - part 2
3 Thursday, 25 March 2010 19:47
E.e.e
(Apologies for these comments appearing out of order - I didn't realise immediately that the second had not appeared due to posts' having to be more than 60 seconds apart.)

Which leaves you with China, a country notorious for the most appalling human rights abuses, particular in the area of human reproduction. Forced abortions, forced sterilisations, forced IUD insertions, where not only psychological pressure but physical force are also used, and the system is implemented using paid informers, Gestapo-like monitoring of women's sexual histories, and sometimes even prison for people who refuse. Is this what you are suggesting? The only countries that I know of which have forced abortion/sterilisation/IUD insertion policies aren't doing them for the sake of improving public health, they're either desperate population measures or they are aimed at certain groups on political or racist grounds, such as the targeting of Romani women in Slovakia. It is also common in these countries for the medical procedures to be carried out in non-sterile conditions, thus causing a high rate of infection and even death.
Get your facts right - part 3
2 Thursday, 25 March 2010 19:44
E.e.e
I'd really like to know, because you're hinting at sterilising or denying medical treatment to people with serious medical conditions, and I happen to have one myself. It may or may not be inheritable. We don't yet know, because despite its being completely devastating and relatively widespread, it is very little researched. However, don't worry. It is exceedingly unlikely that I will be able to have children, and the factor that is stopping me is one that I'm sure you'll approve of. I don't get sufficient medical care (again, the lack of research means a lack of medical treatment - currently there is none) and get wildly insufficient support from social services, so that I am continuing to get more and more ill and don't even have an adequate standard of living myself (e.g. being able to access enough food, frequent enough bathing etc.), let alone the support I would need to be able to bring up a child. You might want to support the money the NHS puts into contraception, because if it wasn't for free, effective and readily available contraception, I wouldn't be able to make this choice. Or would you simply suggest that people with disabilities are banned from having sex?
Get your facts right - part 1
1 Thursday, 25 March 2010 19:43
E.e.e
"It is common for Jewish couples to take genetic tests before marriage – and to call off the nuptials if they don’t get the all clear."

By "common", you'll mean "rare", then. I'm Jewish, I have a great deal of family in Israel, and while I am aware that Jews have higher rates of some medical conditions - and lower rates of others, which I bet you didn't know - I have never in my life heard of any Jewish couple getting genetic testing as a routine part of an engagement, nor that they would then break off the engagement if they did not like the results. Your article is discussing a very small percentage of Jews, and it's looking specifically at the ultra-religious, who form a small minority. One of my Israeli cousins is unable to have children for medical reasons. Her husband knew this when they met. Did they break up over this? Of course not, they went for assisted reproduction, using his sperm and an egg donor. It was partly state-funded and partly privately-funded. Ultra-Orthodox Jews wouldn't do this as they are opposed to assisted reproduction, along with contraception, and this is why they may choose to break off an engagement instead. But they are in no way representative of a majority, and are more like 7% of American Jewry, for instance.

It's also worthy of note that approximately 50% of Jews marry non-Jews these days, which is reducing the differences in genetic risk. This is over the entire Jewish population; for the very small ultra-Orthodox groups which your link refers to, who do not marry out, the genetic pool is shrinking as their population declines, so again they are in no way representative of Jews overall.

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